| 1 |
引言 |
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| 2 |
细胞周期 |
Evans, T., E. T. Rosenthal, J. Youngblom, D. Distel, and T. Hunt.
"Cyclin: A Protein Specified by Maternal mRNA in Sea Urchin Eggs that Is
Destroyed at each Cleavage Division." Cell 33, no. 2 (1983):
389-396. (PDF)#
Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston,
and T. Chittenden. "The Transcription Factor E2F Interacts with the
Retinoblastoma Product and a p107-Cyclin A Complex in a Cell
Cycle-Regulated Manner." Cell 68, no. 1 (1992):
157-166. |
| 3 |
G1期和DNA复制的起始 |
Donovan, S., J. Harwood, L. S. Drury, and J. F. Diffley.
"Cdc6p-Dependent Loading of Mcm Proteins onto Pre-Replicative Chromatin in
Budding Yeast." Proceedings of the National Academy of Sciences of the
United States of America 94, no. 11 (1997): 5611-5616. (PDF)#
Mailand, N., and J. F. Diffley. "CDKs Promote DNA Replication Origin
Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent
Proteolysis." Cell 122, no. 6 (2005): 915-926. (PDF)# |
| 4 |
S期和复制叉移动 |
Dimitrova, D. S., and D. M. Gilbert. "The Spatial Position and
Replication Timing of Chromosomal Domains Are both Established in Early G1
Phase." Molecular Cell 4, no. 6 (1999): 983-993. (PDF)#
Moyer, S. E., P. W. Lewis, and M. R. Botchan. "Isolation of the
Cdc45/Mcm2-7/GINS (CMG) Complex, a Candidate for the Eukaryotic DNA
Replication Fork Helicase." Proceedings of the National Academy of
Sciences of the United States of America 103, no. 27 (2006): 10236-10241.
(PDF - 1.7
MB)# |
| 5 |
DNA复制中细胞周期的调控 |
Hayles, J., D. Fisher, A. Woollard, and P. Nurse. "Temporal Order of S
Phase and Mitosis in Fission Yeast Is Determined by the State of the
p34cdc2 Mitotic B Cyclin Complex." Cell 78, no. 5 (1994):
813-822.
Nguyen, V. Q., C. Co, and J. J. Li. "Cyclin-Dependent Kinases Prevent
DNA Re-Replication through Multiple Mechanisms." Nature 411, no.
6841 (2001): 1068-1073. (PDF)# |
| 6 |
检验点 |
Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan.
"Wild-Type p53 Is a Cell Cycle Checkpoint Determinant Following
Irradiation." Proceedings of the National Academy of Sciences of the
United States of America 89, no. 16 (1992): 7491-7495. (PDF - 1.5
MB)#
Katou, Y., Y. Kanoh, M. Bando, H. Noguchi, H. Tanaka, T. Ashikari,
K.Sugimoto, and K. Shirahige. "S-Phase Checkpoint Proteins Tof1 and Mrc1
Form a Stable Replication-Pausing Complex." Nature 424, no. 6952
(2003): 1078-1083. |
| 7 |
DNA修复 |
Bienko, M., C. M. Green, N. Crosetto, F. Rudolf, G. Zapart, B. Coull,
and P. Kannouche, et al. "Ubiquitin-Binding Domains in Y-Family
Polymerases Regulate Translesion Synthesis." Science 310, no.
5755 (2005): 1821-1824.
Spagnolo, L., A. Rivera-Calzada, L. H. Pearl, and O. Llorca. "Three
Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on
DNA and its Implications for DNA DSB Repair." Molecular Cell 22,
no. 4 (2006): 511-519. |
| 8 |
期中作业 |
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| 9 |
发育和核内复制 |
Verkest, A., C. L. Manes, S. Vercruysse, S. Maes, E. Van Der Schueren,
T. Beeckman, P. Genschik, M. Kuiper, D. Inze, and L. De Veylder. "The
Cyclin-Dependent Kinase Inhibitor KRP2 Controls the Onset of the
Endoreduplication Cycle during Arabidopsis Leaf Development through
Inhibition of Mitotic CDKA; 1 Kinase Complexes." The Plant Cell
17, no. 6 (2005): 1723-1736. (PDF)#
Gregoire, D., K. Brodolin, and M. Mechali. "HoxB Domain Induction
Silences DNA Replication Origins in the Locus and Specifies a Single
Origin at its Boundary." EMBO Reports 7, no. 8 (2006):
812-816. |
| 10 |
重组和减数分裂 |
Borde, V., A. S. Goldman, and M. Lichten. "Direct Coupling between
Meiotic DNA Replication and Recombination Initiation." Science
290, no. 5492 (2000): 806-809.
Bhalla, N., and A. F. Dernburg. "A Conserved Checkpoint Monitors
Meiotic Chromosome Synapsis in Caenorhabditis Elegans." Science
310, no. 5754 (2005): 1683-1686. |
| 11 |
DNA复制和癌症 |
Tanaka, S. and J. F. Diffley. "Deregulated G1-Cyclin Expression Induces
Genomic Instability by Preventing Efficient Pre-RC Formation." Genes
& Development 16, no. 20 (2002): 2639-2649.
Honeycutt, K. A., Z. Chen, M. I. Koster, M. Miers, J. Nuchtern, J.
Hicks, D. R. Roop, and J. M. Shohet. "Deregulated Minichromosomal
Maintenance Protein MCM7 Contributes to Oncogene Driven Tumorigenesis."
Oncogene 25, no. 29 (2006): 4027-4032. |
| 12 |
靶向复制元件用作化学疗法 |
Li, J. L., Y. C. Cai, X. H. Liu, and L. J. Xian. "Norcantharidin
Inhibits DNA Replication and Induces Apoptosis with the Cleavage of
Initiation Protein Cdc6 in HL-60 Cells." Anti-Cancer Drugs 17,
no. 3 (2006): 307-314.
Cantero, G., N. Pastor, S. Mateos, C. Campanella, and F. Cortes.
"Cisplatin-Induced Endoreduplication in CHO Cells: DNA Damage and
Inhibition of Topoisomerase II." Mutation Research 599, no. 1-2
(2006): 160-166. |
| 13 |
病毒再编程的细胞周期 |
Yew, P. R. and A. J. Berk. "Inhibition of p53 Transactivation Required
for Transformation by Adenovirus Early 1B Protein." Nature 357,
no. 6373 (1992): 82-85.
Wiebusch, L., R. Uecker, and C. Hagemeier. "Human Cytomegalovirus
Prevents Replication Licensing by Inhibiting MCM Loading Onto Chromatin."
EMBO Reports 4, no. 1 (2003): 42-46. (PDF)# |
| 14 |
期末作业陈述 |
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