学生可以从下列主题中选择一个，并阅读该主题下所列出的有关文章 , 以准备他们的课堂报告。

钾通道

Choe. "Potassium Channel Structures," Nat Rev Neurosci. 2002 Feb;3(2):115 [background and review].

Doyle, et al. "The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity," Science. 1998 Apr 3;280(5360):69-77 [primary article].

He, et al. "Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization," Cell. 2002 Jan 25;108(2):271-82 [primary article].

Pierce, et al. "Seven-Transmembrane Receptors," Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50 [background and review].

神经诱导

Piccolo, et al. "Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4." Cell. 1996 Aug 23;86(4):589-98.

区域化

Houart, et al. "Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling." Neuron. 2002 Jul 18;35(2):255-65.

神经形成与迁移

Wu, et al. "Directional guidance of neuronal migration in the olfactory system by the protein Slit." Nature. 1999 Jul 22;400(6742):331-6.

细胞神经生物学，亚细胞的特异化

Hering and Sheng. "Dendritic spines: structure, dynamics and regulation." Nat Rev Neurosci. 2001 Dec;2(12):880-8. [Background and Review].

Shi, et al. "Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity." Cell. 2003 Jan 10;112(1):63-75. [Primary Article].

蛋白质靶向与信号复合体

Sheng and Sala. "PDZ domains and the organization of supramolecular complexes." Annu Rev Neurosci. 2001;24:1-29. [Background and Review].

Tsunoda, et al. "A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade." Nature. 1997 Jul 17;388(6639):243-9.[Primary Article].

神经元的定向和分化

Wichterle, et al. "Directed Differentiation of Embryonic Stem Cells into Motor Neurons." Cell. 2002 Aug 9;110(3):385-97.

轴突导向I：生长锥的能动性；因子和受体

Stein and Tessier-Lavigne. "Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex." Science. 2001 Mar 9;291(5510):1928-38. Epub 2001 Feb 08.

轴突导向II：细胞质的信号传导途径，轴突与靶标的识别

Schmucker, et al. "Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity." Cell. 2000 Jun 9;101(6):671-84.

细胞的存活和死亡I：神经营养的假说，生存因素/受体

Kuruvilla, et al. "Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons." Neuron. 2000 Sep;27(3):499-512.

细胞的存活和死亡 II：细胞死亡的途径，在发育方面和病理方面的意义

Nakatomi, et al. "Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors." Cell. 2002 Aug 23;110(4):429-41.

突触传递I (突触前的机制)

Marek and Davis. "Transgenically Encoded Protein Photoinactivation (FlAsH-FALI): Acute Inactivation of Synaptotagmin I." Neuron. 2002 Dec 5;36(5):805-13.

突触传递II (突触后的机制)

Sheng and Lee. "AMPA Receptor Trafficking and the Control of Synaptic Transmission." Cell. 2001 Jun 29;105(7):825-8. [Background and Review].

Shi, et al. "Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons." Cell. 2001 May 4;105(3):331-43.[Primary Article].

可塑性研究的模式系统：突触前及突触后的机制

Antonov, et al. "The contribution of facilitation of monostnaptic PSPs to dishabituation and sensitization of the Aplysia siphon withdrawal reflex." J Neurosci. 1999 Dec 1;19(23):10438-50. [Primary Article].

Baeumont and Zucker. "Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels." Nat Neurosci. 2000 Feb;3(2):133-41.[Background Reading].

Regehr and Stevens. "Physiology of Synaptic Transmission and Short-Term Plasticity, Chap. 3 in Synaptic Physiology. [Important background reading] [From _Synapses_] Edited by Cowan, Sudhof, and Stevens, 2001, pp. 135-175.

神经肌肉接点处的可塑性

Barber and Lichtman, "Activity-Driven Synapse Elimination Leads Paradoxically to Domination by Inactive Neurons." J Neurosci. 1999 Nov 15;19(22):9975-85. [Background Reading].

Coleman, et al. "Alterations in Synaptic Strength Preceding Axon Withdrawal." [Primary Article], 1997.

鸟鸣：行为与神经环路水平的可塑性

Boettiger and Doupe, "Developmentally Restricted Synaptic Plasticity in a Songbird Nucleus Required for Song Learning." Neuron. 2001 Sep 13;31(5):809-18.[Background Reading].

Livingston, et al. "Slow NMDA-EPSCs at synapses critical for song development are not required for song learning in zebra finches." Nat Neurosci. 2000 May;3(5):482-8.[Primary Article].

多模式图和感受性在使用中的提高

Gutfreund, et al. "Gated Visual Input to the Central Auditory System." Science. 2002 Aug 30;297(5586):1556-9.[Background Reading].

Zheng and Knudsen, "Functional Selection of Adaptive Auditory Space Map by GABAA-Mediated Inhibition." Science. 1999 May 7;284(5416):962-5. [Primary Article].

非视觉皮质区的可塑性

Sin, et al. "Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases." Nature. 2002 Oct 3;419(6906):475-80.[Primary Article].

Zhang, et al. "Visual input induces long-term potentiation of developing retinotectal synapses." Nat Neurosci. 2000 Jul;3(7):708-15. [Background Reading].

视觉皮质的可塑性: 研究历史和争论

Hata, et al. "Selective Pruning of More Active Afferents When Cat Visual Cortex Is Pharmacologically Inhibited." Neuron. 1999 Feb;22(2):375-81. [Primary Article].

Rittenhouse, et al. "Monocular deprivation induces homosynaptic long-term depression in visual cortex." Nature. 1999 Jan 28;397(6717):347-50. [Background Reading].

大脑皮质可塑性的分子机制

Hensch, et al. "Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex." Science. 1998 Nov 20;282(5393):1504-8.[Primary Article].

Kilman, et al. "Activity Deprivation Reduces Miniature IPSC Amplitude by Decreasing the Number of Postsynaptic GABAA Receptors Clustered at Neocortical Synapses." J Neurosci. 2002 Feb 15;22(4):1328-37.[Background Reading], 2002.

可塑性和 GABA(伽马氨基丁酸) 介导的抑制作用

Hardingham, et al. "Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways." Nat Neurosci. 2002 May;5(5):405-14.[Background Reading].

Owens, et al. "Excitatory GABA Responses in Embryonic and Neonatal Cortical Slices Demonstrated by Gramicidin Perforated-Patch Recordings and Calcium Imaging." J Neurosci. 1996 Oct 15;16(20):6414-23.[Primary Article].