| 1 |
生化过程的合成策略 |
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| 2 |
生化过程概述 |
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| 3 |
细胞破碎 |
Shutte, H., and M. R. Kula. "Cell Disruption and
Isolation of Non-Secreted Products." In Biotechnology: A Multi-Volume
Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G.
Stephanopoulos. New York, NY: VCH Publishers, Inc., 1993, pp. 505-526.
ISBN: 3527283137. |
| 4 |
固液分离：离心 |
Datar, R. V., and C. G. Rosen. "Cell and Cell
Debris Removal: Centrifugation and Crossflow Filtration." In
Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3,
Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH
Publishers, Inc., 1993, pp. 469-486. ISBN: 3527283137. |
| 5 |
色谱分析 |
Palmer, D. E., and R. V. Dove. "Ion Exchange
Recovery of Proteins." In Comprehensive Biotechnology. Vol. 2,
The Principles of Biotechnology: Engineering Considerations.
Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press
Ltd., 1985, pp. 481-488. ISBN: 008032510.
Yarmush, M. L., K.
Antonsen, and D. M. Yarmush. "Molecular Sieve Chromatography." In
Comprehensive Biotechnology. Vol. 2, The Principles of
Biotechnology: Engineering Considerations. Edited by C. L. Cooney,
and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 489-505.
ISBN: 008032510.
Skoog, D. A., D. M. West, and F. J. Holler. "An
Introduction to Chromatographic Methods." In Fundamentals of
Analytical Chemistry. New York, NY: Saunders College Publishing,
1992, pp. 665-693. ISBN: 0030749220. |
| 6 |
蛋白质再折叠 |
Cleland, J. L., and D. I. C. Wang. "In
vitro Protein Refolding." In Biotechnology: A Multi-Volume
Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G.
Stephanopoulos. New York, NY: VCH Publishers, Inc., 1993, pp. 527-555.
ISBN: 3527283137.
Datar, R. V., T. Cartwright, and C. G. Rosen.
"Process Economics of Animal Cell and Bacterial Fermentations - A Case
Study Analysis of Tissue Plasminogen Activator." Bio/Technology
11, no. 3 (1993) 349-357. |
| 7 |
固液分离：过滤 |
Ladisch, M. R. "Filtration." In Bioseparations
Engineering: Principles, Practice, and Economics. New York, NY: John
Wiley and Sons, 2001, pp. 36-47. ISBN: 0471244767. |
| 8 |
膜过滤和离心的应用 |
Datar, R. V., and C. G. Rosen. "Cell and Cell
Debris Removal: Centrifugation and Crossflow Filtration." In
Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3,
Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH
Publishers, Inc., 1993, pp. 487-503. ISBN: 3527283137.
Tutunjian,
R. S. "Ultrafiltration Processes in Biotechnology." In Comprehensive
Biotechnology. Vol. 2, The Principles of Biotechnology:
Engineering Considerations. Edited by C. L. Cooney, and A. E.
Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 411-437. ISBN:
008032510. |
| 9 |
旋转式真空过滤 |
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| 10 |
过程的综合、分析和模拟 |
Shuler, M. L., and F. Kargi. "Separation of
Soluble Products." In Bioprocess Engineeing. Englewood Cliffs,
NJ: Prentice Hall PTR, 1992, pp. 325-331. ISBN: 0134782151.
Kelly,
B. D., and T. A. Hatton. "Protein Purification by Liquid-Liquid
Extraction." In Biotechnology: A Multi-Volume Comprehensive
Treatise. Vol. 3, Bioprocessing. Edited by G.
Stephanopoulos. New York, NY: VCH Publishers, Inc., 1993, pp. 593-616.
ISBN: 3527283137. |
| 11 |
过程模拟 |
Petrides, D., C. L. Cooney, and L. B. Evans. "An
Introduction to Biochemical Process Design." In Chemical Engineering
Problems in Biotechnology. Edited by M. L. Shuler. New York, NY:
American Institute of Chemical Engineers, 1989, pp. 351-391. ISBN:
0816904693.
Ernst, S., et al. "Process Simulation for Recombinant
Protein Production: Cost Estimation and Sensitivity Analysis for
Heparinase I Expressed in Escherichia Coli." Biotechnology
and Bioengineering 53, no. 6 (1997): 575-582. |
| 12 |
创新案例学习 |
Bioprocess Design and Simulation Handout (PDF)
(Courtesy of Steve Griffiths, PhD. Used with
permission.)
Insulin Case Study
Ladisch, M. R., and
K. L. Kohlmann. "Recombinant Human Insulin." Biotechnology
Progress 8, no. 6 (1992): 469-478.
Petrides, D., E. Sapidou,
and J. Calandranis. "Computer-Aided Process Analysis and
Economic-Evaluation for Biosynthetic Human Insulin Production - A Case
Study." Biotechnology and Bioengineering 48, no. 5 (1995):
529-541. |
| 13 |
过程确认 |
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