课程的阅读资料包括课本、选择的文献、以及一些推荐的补充材料。
课本的阅读见教材:
Golan, D., et. al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Philadelphia, PA: Lippincott Williams and Wilkins, 2004. ISBN: 0781746787.
The emphasis, particularly in long assignments like antibiotics, should be on mechanisms of action and principles of therapy rather than minutiae about individual drugs.
课程参考读物
| LEC # |
题目 |
阅读手册 |
推荐的文献 |
| 1 |
绪论
受体 / 量效关系 |
pp. 3-26 |
|
| 2 |
药物代谢动力学 I
药物代谢动力学 II |
pp. 27-43 |
|
| 3 |
临床文献阐述
拟胆碱药物
病案: 抗胆碱酯酶药物 |
pp. 55-106, and 724-725 |
Bernard, G. R., et. al. "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis." The New England Journal of Medicine 344, no. 10 (2001): 699-709. |
| 4 |
药物代谢
遗传药理学
病案: 抗凝血药物, 柳磺吡啶 |
pp. 45-54, 803-809, and 350-353 |
|
| 5 |
自主神经系统药理学 I
自主神经系统药理学 II
病案: 嗜铬细胞瘤, 哮喘 |
pp. 205-228, 71-86, 107-120, and 695-708 |
|
| 6 |
局部麻醉药
抗心律失常药
病案: 毒物控制, 可卡因 |
pp. 205-228, 121-136, 267-284, and 719-743 |
Buxton, Alfred E., et. al. "A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease." The New England Journal of Medicine 341, no. 25 (1999): 1882-1890. |
| 7 |
药物代谢动力学 III
抗炎症药物
病案: 青光眼 |
pp. 781-787, and 617-646 |
Weinblatt, Michael E., et. al. "A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor: Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate." The New England Journal of Medicine 340, no. 4 (1999): 253-259.
Edwards, David A., et. al. "Large Porous Particles for Pulmonary Drug Delivery." Science 276, no. 5320 (1997): 1868-1871.
Langer, Robert J. "New Methods of Drug Delivery." Science 249, no. 4976 (1990): 1527-1533. |
| 8 |
血管活性药物 I
血管活性药物 II: 心力衰竭
病案: 遗传药理学, 甲状腺疾病
|
pp. 285-333, 375-399, and 415-424 |
Wing, Lindon M. H., et. al. "A Comparison of Outcomes with Angiotensin-converting-enzyme Inhibitors and Diuretics for Hypertension in the Elderly." The New England Journal of Medicine 348, no. 7 (2003): 583-592.
The Digitalis Investigation Group. "The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure." The New England Journal of Medicine 336, no. 8 (1997): 525-533. |
| 9 |
降血脂药物
病案: 胎盘转运, 痛风 |
pp. 357-374, 447, and 709-715 |
Knopp, Robert H. "Drug Treatment of Lipid Disorders." The New England Journal of Medicine 341, no. 7 (1999): 498-511. |
| 10 |
抗组胺药物
实体器官移植免疫
病案: 止吐药, 老年药理学 |
pp. 647-654, 683-694, and 667-681 |
Simons, F. Estelle R. "Advances in H1-Antihistamines." The New England Journal of Medicine 351, no. 21 (2004): 2203-2217. |
| 11 |
药物发展 |
pp. 747-756, and 791-801 |
Lazo, John S., and Peter Wipf. "Combinatorial Chemistry and Contemporary Pharmacology." The Journal of Pharmacology and Experimental Therapeutics 298, no. 8 (2000): 705-709. |
| 12 |
神经系统药理学 I: 抗运动障碍疾病药物
一氧化氮
病案: 安慰剂, 急性肾功能衰竭 |
pp. 161-178, and 40 |
Ichinose, Fumito, Jesse D. Roberts, Jr., and Warren M. Zapol. "Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential." Circulation 109, no. 25 (2004): 3106-3111.
Steudel, Wolfgang, William E. Hurford, and Warren M. Zapol. "Inhaled Nitric Oxide: Basic Biology and Clinical Applications." Anesthesiology 91, no. 4 (1990): 1090-1121. |
| 13 |
神经系统药理学 II: 抗焦虑药和抗抑郁药
神经系统药理学 III: 抗惊厥药
病案: 锂盐 酒精 |
pp. 139-159, 179-204, and 260-261 |
|
| 14 |
抗菌药 I
抗菌药 II
病案: 药物过敏, 偏头痛 |
pp. 493-504, 535-544, 565-578, and 603-613 |
Rodvold, Keith A. "Pharmacodynamics of Antiinfective Therapy: Taking What We Know to the Patient's Bedside." Pharmacotherapy 21, no. 11, Pt 2 (2001): 319S - 330S. |
| 15 |
化疗药理 I
化疗药理 II
病案: 叶酸, 口服降血糖药物 |
pp. 505-554, and 457-471 |
|
| 16 |
阿片类 I
阿片类 II
病案: 癌症 - 镇痛, 药物滥用 |
pp. 229-263 |
Kieffer, B. L. "Opioids: First Lessons from Knockout Mice." Trends in Pharmacological Sciences 20, no. 1 (1999): 19-26. |
一些题目会有额外的文献资料，包括:
Hardman, J. G., et. al., eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001. ISBN: 0071354697.
Katzung, B., et. al., eds. Basic and Clinical Pharmacology. 9th ed. New York, NY: McGraw-Hill, 2004. ISBN: 0071410929.
Katzung 的文献对下列题目特别有帮助:
- 柳磺吡啶和溃疡性结肠炎
- 嗜铬细胞瘤
- 青光眼
- 发育畸形和胎盘转运
- 止吐药
- 老年药理学
- 安慰剂
- 药物过敏
- 偏头痛