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下面讲义是本课程需要的，同时被列在下面表格中的读物按讲课安排需要参考。Shortliffe, E. H., L. E. Perreault, G. Wiederhold, and L. M. Fagan.医学信息学：计算机在卫生保健和生物医学中的应用。第二版。Springer, 2001.
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讲座 # |
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主题 |
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参考读物 |
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1 |
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介绍: 现代医学和医学实践的性质 |
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Shortliffe的第一、第二章 |
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2 |
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医学数据的性质: 它的问题在哪里？不在哪里？ |
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Shortliffe的第九、第十章 |
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3 |
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医学遗传: 生物信息中心 |
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"Initial Sequencing and Analysis of the Human Genome." International Human Genome Sequencing Consortium, 409 (2001): Macmillan Magazines Ltd.
Chakravarti, Aravinda. "Population Genetics — Making Sense Out of Sequence." Nature Genetics Supplement 21 (Jan 1999): Ohio: Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland.
Brown, Patrick O., and David Botstein. "Exploring the New World of the Genome with DNA Microarrays." Nature Genetics Supplement 21 (Jan 1999): Stanford, California: Departments of Biochemistry and Genetics, and the Howard Hughes Medical Institute, StanfordUniversitySchoolof Medicine.
"Distinct Types of Diffuse Large B-cell Lymphoma Identified by Gene Expression Profiling." Nature 403 (3 Feb. 2000): Macmillan Magazines Ltd.
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4 |
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病人鉴别 |
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Fellegi, Ivan P., and Allen B. Sunter. "A Theory for Record Linkage." Journal of American Statistical Association 64 (328) (Dec 1969): 1183-1210. |
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5 |
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反生物恐怖 |
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Shortliffe的第十一章 |
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6 |
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工作流程，决策支持和数据收集 |
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Mueller, Ganslandt, Frankewitsch, Krieglstein, Senninger, and Prokosch. "Workflow Analysis and Evidence-Based Medicine: Towards Integration of Knowledge-Based Functions in Hospital Information Systems." Germany: University of Muenster.
Coiera, Enrico. "Clinical Communication: A New Informatics Paradigm." Jamia (1996): UK.
Coiera, Enrico. "When Conversation is Better than Computation." Jamia (14 Jan. 2000): Washington DC.
Kohane, Isaac S., Philip Greenspun, James Fackler, Christopher Cimino, and Peter Szolovits. "Application of Technology in Building National Electronic-Medical Record Systems via the World Wide Web." Journal of the American Medical Informatics Association 3 (3) (May/Jun 1996).
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7 |
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计算对企业的支持 |
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8 |
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医学数据、标准词汇库与信息标准 |
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Shortliffe的第六、第十、第十一章 |
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9 |
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病人数据保密和安全 |
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Shortliffe的第七章
Barrows, Randolph. C. Jr., Paul D. Clayton. "Privacy Confidentiality and EMR." Journal of the American Medical Informatics Association 3 (2) (Mar/Apr 1996).
选读
- For the Record. Protecting Electronic Health Information. Washington D.C. : National Academy Press, 1997.
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10 |
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用计算机处理医师指令: 用技术改善病人的安全 |
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11 |
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健康保健中变量的减少 |
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12 |
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整合和数据分享或医学数据质量改进 |
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13 |
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远程医学 |
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Shortliffe的第十四章 |
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14 |
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后基因组时代的人类遗传学 |
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Lander, Eric S. "Array of hope." Nature Genetics Supplement 21 (1999): Cambridge, Massachusetts: America Inc.
------., and Nicholas J. Schork. "Genetic Dissection of Complex Traits." Science, New Series, 265 (5181) (30 Sep. 1994): 2037-2048.
"Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome." Science 280 (15 May 1998): 1077.
http://www.sciencemag.org
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15 |
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基因医学II: 表达排列，基因聚类和距离韵律学 |
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Michael, P. S. Brown, William Noble Grundy, David Lin, Nello Cristianini, Charles Walsh Sugnet, Terence S. Furey, Manuel Ares, Jr., and David Haussler. "Knowledge-based Analysis of Microarray Gene Expression Data by Using Support Vector Machines." PNAS 97 (1) (4 Jan. 2000): 262-267. |
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16 |
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决策分析和决策支持 |
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Shortliffe的第十五、第十六章
Szolovits, P. "Uncertainty and Decisions in Medical Informatics." Methods of Information in Medicine 34 (1995): 111–21.
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17 |
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基因中的因果关系 |
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"The Transcriptional Program in the Response of Human Fibroblasts to Serum." Science 283 (1 Jan. 1999).
www.sciencemag.org
Ramoni, Marco F., Paola Sebastiani, and Isaac S. Kohane. "Cluster Analysis of Gene Expression Dynamics." PNAS. Edited by Louis M. Kunkel.
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18 |
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高级专家系统 |
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Shortliffe的第十二、第十三章 |
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19 |
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病人监测 |
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20 |
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基因医学III：基因学介绍 |
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21 |
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基因医学IV： 基因型与表型的关联 |
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22 |
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基因医学V： 反工程 |
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Zoltan. "The Perils and Promises of Massively Parallel Biology." Chap. 5 in Genetic Network Analysis, 2002: pp. 23. |
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23 |
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学生报告 |
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24 |
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学生报告 |
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25 |
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学生报告 |
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26 |
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学生报告 |
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